Protein control of iron-sulfur cluster redox potentials.
نویسندگان
چکیده
منابع مشابه
Redox Control of the Human Iron-Sulfur Repair Protein MitoNEET Activity via Its Iron-Sulfur Cluster.
Human mitoNEET (mNT) is the first identified Fe-S protein of the mammalian outer mitochondrial membrane. Recently, mNT has been implicated in cytosolic Fe-S repair of a key regulator of cellular iron homeostasis. Here, we aimed to decipher the mechanism by which mNT triggers its Fe-S repair capacity. By using tightly controlled reactions combined with complementary spectroscopic approaches, we ...
متن کاملIron-sulfur cluster biosynthesis.
Iron-sulfur (Fe-S) clusters are present in more than 200 different types of enzymes or proteins and constitute one of the most ancient, ubiquitous and structurally diverse classes of biological prosthetic groups. Hence the process of Fe-S cluster biosynthesis is essential to almost all forms of life and is remarkably conserved in prokaryotic and eukaryotic organisms. Three distinct types of Fe-...
متن کامل[2Fe-2S] cluster transfer in iron-sulfur protein biogenesis.
Monothiol glutaredoxins play a crucial role in iron-sulfur (Fe/S) protein biogenesis. Essentially all of them can coordinate a [2Fe-2S] cluster and have been proposed to mediate the transfer of [2Fe-2S] clusters from scaffold proteins to target apo proteins, possibly by acting as cluster transfer proteins. The molecular basis of [2Fe-2S] cluster transfer from monothiol glutaredoxins to target p...
متن کاملRedox Reactions of the Iron-Sulfur Cluster in a Ribosomal RNA Methyltransferase, RumA
An unprecedented [4Fe-4S] iron-sulfur cluster was found in RumA, the enzyme that methylates U1939 in Escherichia coli 23 S ribosomal RNA (Agarwalla, S., Kealey, J. T., Santi, D. V., and Stroud, R. M. (2002) J. Biol. Chem. 277, 8835–8840; Lee, T. T., Agarwalla, S., and Stroud, R. M. (2004) Structure 12, 397–407). Methyltransferase reactions do not involve a redox step. To understand the structur...
متن کاملFeedback regulation of iron-sulfur cluster biosynthesis.
I clusters ([Fe-S] clusters) represent one of nature’s simplest, functionally versatile, and perhaps most ancient prosthetic groups (1). Among the familiar types of [Fe-S] clusters are [2Fe2S] and [4Fe-4S] clusters, which usually are attached to their protein partners by four cysteine thiol ligands (Fig. 1). Proteins that contain one or more [Fe-S] clusters are commonly called [Fe-S] proteins, ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1992
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)35647-3